As a general rule, I don't like it when people ask questions. Usually, their questions have either already been answered or are just plain dumb. But hey, maybe that's just me.
No, what really gets me going, is when people ask me or the people around me questions during a movie, about the movie. If you were paying attention to the movie, maybe you would actually know what was going on instead of having to ask about it every two seconds. Really, the character JUST said that. And for heaven's sake, PLEASE don't ask me about what's going to happen later on in the movie when I'd already made it clear that it's my first time watching it too.